LC427 | LRBA-CTLA4 inhibitor, CTLA4 degrader | Probechem Biochemicals

Chemical Structure : LC427

加入收藏

LC427 (LC-427)

货号: PC-25905Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

LC427 (LC-427) is a specific small molecule inhibitor of LRBA-CTLA4 interaction with IC50 of 0.18 uM, facilitates the lysosomal degradation of CTLA4, binds directly to PH-BEACH domain of LRBA with Kd of 19.6 uM.
LC427 mainly inhibits the interaction of LRBA with intracellular CTLA4, but not with the surface CTLA4 or soluble CTLA4.
LC427 disrupts LRBA-CTLA4 interactions in HEK293T cells transfected with LRBA PH and CTLA4, and human PBMCs.
LC427 triggers CTLA4 lysosomal degradation in a time-dependent manner and a dose-dependent manner in HEK293T cells overexpressing LRBA and CTLA4 proteins.
LC427 reduces CTLA4 expression in mouse and human T cells.
LC427 inhibits apoptosis and enhances the functions of activated T cells.
LC427 promotes antitumor immunity in multiple tumor models, triggers antitumor immunity in an LRBA/CTLA4-dependent manner.

物理化学性质&存储条件

分子量	291.36
分子式	C17H17N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-(piperazin-1-yl)pyrimidin-4-yl)quinoline

参考文献

1. Ge X, et al. Nat Commun. 2025 Dec 14. doi: 10.1038/s41467-025-67365-5.

LC427 (LC-427)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

LC427 (LC-427)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.