LBL1 | Lamin A inhibitor | Probechem Biochemicals

Chemical Structure : LBL1

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LBL1 (Lamin A inhibitor LBL1)

货号: PC-63448Not For Human Use, Lab Use Only.

LBL1 (Lamin A inhibitor LBL1) is a novel pyrroloquinazoline compound with significant anticancer activity, targets nuclear lamins and binds to the coiled-coil domain of lamin A (Kd=5.11 uM).

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生物&药学活性

LBL1 (Lamin A inhibitor LBL1) is a novel pyrroloquinazoline compound with significant anticancer activity, targets nuclear lamins and binds to the coiled-coil domain of lamin A (Kd=5.11 uM).
LBL1 demonstrates growth inhibitory activities against MDA-MB-468 and MDA-MB-231 breast cancer cell lines with GI50 of 0.44 and 1.60 uM, respectively.
LBL1 binds to LA(1-387) both in vitro and in living cells.

物理化学性质&存储条件

分子量	353.385
分子式	C21H15N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-amino-7H-pyrrolo[3,2-f]quinazolin-3-yl)-2-naphthamide

参考文献

1. Chen J, et al. Medchemcomm. 2013 Sep 1;4(9):1275-1282.

2. Li BX, et al. ACS Chem Biol. 2018 Apr 19. doi: 10.1021/acschembio.8b00266.

LBL1 (Lamin A inhibitor LBL1)

生物&药学活性

物理化学性质&存储条件

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LBL1 (Lamin A inhibitor LBL1)

生物&药学活性

物理化学性质&存储条件

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