LB42908 |CAS:226927-89-5 Probechem Biochemicals

Chemical Structure : LB42908

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LB42908 (LB 42908;LB-42908)

货号: PC-63362Not For Human Use, Lab Use Only.

LB42908 is a highly potent, selective, orally active inhibitor of Ras farnesyltransferase (FTase) with IC50 of 0.9 nM against H-Ras and 2.4 nM against K-Ras..

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生物&药学活性

LB42908 is a highly potent, selective, orally active inhibitor of Ras farnesyltransferase (FTase) with IC50 of 0.9 nM against H-Ras and 2.4 nM against K-Ras.

物理化学性质&存储条件

分子量	533.62
分子式	C32H31N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(4-methylpiperazin-1-yl)methanone

参考文献

1. Lee H, et al. Bioorg Med Chem Lett. 2001 Dec 3;11(23):3069-72.

2. Kim HJ, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3067-71.

3. Kim HS, et la. Toxicol Appl Pharmacol. 2006 Sep 15;215(3):317-29.

4. Lee SK, et al. Int J Cancer. 2006 May 1;118(9):2172-81.

LB42908 (LB 42908;LB-42908)

生物&药学活性

物理化学性质&存储条件

参考文献

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LB42908 (LB 42908;LB-42908)

生物&药学活性

物理化学性质&存储条件

参考文献

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