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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-LB-100
LB-100

Chemical Structure : LB-100

CAS No.: 1632032-53-1

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LB-100 (LB100)

货号: PC-45470Not For Human Use, Lab Use Only.

LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor.

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5 mg ￥980 In stock
10 mg ￥1380 In stock
25 mg ￥2280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor.
LB100 exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM.
LB100 synergistically enhances the activity of doxorubicin and induces expression of HIF-1α and VEGF.
LB100 significantly enhances tumor growth inhibition by cisplatin in vivo.

物理化学性质&存储条件

分子量 268.3089
分子式 C13H20N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

H2O: ≥ 48 mg/mL; DMSO: < 2.9 mg/mL
Chemical Name/SMILES

7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[(4-methyl-1-piperazinyl)carbonyl]-, (1R,4S)-rel-

参考文献

1. Bai XL, et al. Mol Cancer Ther. 2014 Aug;13(8):2062-72.

2. Chang KE, et al. Mol Cancer Ther. 2015 Jan;14(1):90-100.

3. Gordon IK, et al. Mol Cancer Ther. 2015 Jul;14(7):1540-7.

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