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LAVR-289

Chemical Structure : LAVR-289

CAS No.: 2379824-89-0

LAVR-289 (LAVR289)

货号: PC-24684Not For Human Use, Lab Use Only.

LAVR-289 is a novel acyclic nucleoside phosphonate that effectively inhibits viral replication by targeting a specific domain in the poxvirus DNA polymerase, exhibits antiviral activity against HCMV, vaccinia virus (VV) and HSV-1 (TK-) with EC50 of 21 nM, 50 nM and 8.5 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

LAVR-289 is a novel acyclic nucleoside phosphonate that effectively inhibits viral replication by targeting a specific domain in the poxvirus DNA polymerase, exhibits antiviral activity against HCMV, vaccinia virus (VV) and HSV-1 (TK-) with EC50 of 21 nM, 50 nM and 8.5 nM respectively.
LAVR-289 inhibits VACV, CPXV, MPXV, and ASFV in vitro at nanomolar concentrations by acting at the replication stage and directly targeting the viral DNA polymerase.
LAVR-289 potent inhibits VZV wild-type (TK+) (EC50 0.0035 μM, SI 740) and for thymidine kinase VZV deficient strains (EC50 0.018 μM, SI 145), with a low morphological toxicity in cell culture at 100 μM.
LAVR-289 demonstrated protective efficacy in infected animals without toxicity.

物理化学性质&存储条件

分子量 730.88
分子式 C35H63N4O10P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-2-(((2,6-diaminopyrimidin-4-yl)oxy)methyl)-4-((3-(hexadecyloxy)propoxy)(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)but-2-en-1-yl acetate

参考文献

1. Quentin-Froignant C, et al. ACS Infect Dis. 2025 May 19. doi: 10.1021/acsinfecdis.5c00170.

2. Bessières M, et al. Eur J Med Chem. 2024 May 5;271:116412.

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