LAS194046 | pan-JAK inhibitor | Probechem Biochemicals

Chemical Structure : LAS194046

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LAS194046 (LAS-194046, LAS 194046)

货号: PC-73064Not For Human Use, Lab Use Only.

LAS194046 (LAS-194046) is a potent, selective pan-JAK inhibitor with IC50 of 5.46/0.4/ 2.07 nM against JAK1/2/3, less potent in TYK2 activity (IC50=21.8 nM).

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生物&药学活性

LAS194046 (LAS-194046) is a potent, selective pan-JAK inhibitor with IC50 of 5.46/0.4/ 2.07 nM against JAK1/2/3, less potent in TYK2 activity (IC50=21.8 nM).
LAS194046 is effective at blocking cytokine signaling depending on JAK1/JAK3, both in lymphocytes and monocytes, and JAK2/JAK2 in monocytes with IC50 of 16 nM, 26 nM and 37 nM, respectively.
LAS194046 reduces allergen-induced airway inflammation, late asthmatic response, and phosphor-STAT activation in the rat OVA model.

物理化学性质&存储条件

分子量	640.768
分子式	C34H41FN10O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(3-((6-(4-(4-(2-(dimethylamino)ethoxy)benzyl)piperazin-1-yl)-5-fluoro-2-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

参考文献

1. Calbet M, et al. J Pharmacol Exp Ther. 2019 Aug;370(2):137-147.

LAS194046 (LAS-194046, LAS 194046)

生物&药学活性

物理化学性质&存储条件

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LAS194046 (LAS-194046, LAS 194046)

生物&药学活性

物理化学性质&存储条件

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