LAS191954 |CAS:1403947-26-1 Probechem Biochemicals

Chemical Structure : LAS191954

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LAS191954 (LAS-191954;LAS 191954)

货号: PC-60447Not For Human Use, Lab Use Only.

LAS191954 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM.

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生物&药学活性

LAS191954 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM.
LAS191954 displays highest selectivity versus PI3Kα (IC50=8.2 uM) and the lowest versus PI3Kγ and PI3Kβ (IC50=72 and 94 nM respectively).
LAS191954 inhibits pAkt (Thr308) produced through PI3K with IC50 of 7.8 nM in THP-1 cells, inhibits IL2 production with an ID50 of 0.13 mg/kg in rat model of con A.

物理化学性质&存储条件

分子量	397.402
分子式	C20H15N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(1-((6-amino-5-cyanopyrimidin-4-yl)amino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile

参考文献

1. Erra M, et al. ACS Med Chem Lett. 2016 Nov 30;8(1):118-123.

LAS191954 (LAS-191954;LAS 191954)

生物&药学活性

物理化学性质&存储条件

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LAS191954 (LAS-191954;LAS 191954)

生物&药学活性

物理化学性质&存储条件

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