LAKI | K2P channel inhibitor | Probechem Biochemicals

Chemical Structure : LAKI

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LAKI (Light Activated K+ channel Inhibitor)

货号: PC-20745Not For Human Use, Lab Use Only.

LAKI (Light Activated K+ channel Inhibitor) is a specific photoswitchable inhibitor of the pain-related two-pore-domain potassium (K2P) TREK and TRESK channels.

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生物&药学活性

LAKI (Light Activated K+ channel Inhibitor) is a specific photoswitchable inhibitor of the pain-related two-pore-domain potassium (K2P) TREK and TRESK channels.
In the dark or ambient light, LAKI is inactive. However, alternating transdermal illumination at 365 nm and 480 nm reversibly blocks and unblocks TREK/TRESK current in nociceptors, enabling rapid control of pain and nociception in intact and freely moving mice and nematode.
LAKI has an IC50 of 2.45, 1.79, and 1.75 µM for TREK1, TREK2, and TRESK respectively.
LAKI enables optical control of potassium currents in native nociceptors through an endogenous TREK1, TREK2 and TRESK photoblock. LAKI controls pain behavior in freely moving mice.

物理化学性质&存储条件

分子量	345.40
分子式	C21H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=CC=CC(/N=N/C2=CC=CC(C)=C2)=C1)C3=CC=CC=C3OC

参考文献

1. Landra-Willm A, et al. Nat Commun. 2023 Mar 1;14(1):1160.

LAKI (Light Activated K+ channel Inhibitor)

生物&药学活性

物理化学性质&存储条件

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LAKI (Light Activated K+ channel Inhibitor)

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物理化学性质&存储条件

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