LAG-3 inhibitor 11

Chemical Structure : LAG-3 inhibitor 11

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货号: PC-25371Not For Human Use, Lab Use Only.

LAG-3 inhibitor 11 is a potent, small molecule LAG-3 inhibitor, binds LAG-3 with MST KD of 0.41 uM, demonstrates disruption of the LAG-3/MHC II interaction in a cellular assay with EC50 of 0.31 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

LAG-3 inhibitor 11 is a potent, small molecule LAG-3 inhibitor, binds LAG-3 with MST KD of 0.41 uM, demonstrates disruption of the LAG-3/MHC II interaction in a cellular assay with EC50 of 0.31 uM.
LAG-3 inhibitor 11 (10 uM) induces a significant increase in IFN-γ secretion, mirroring the effect observed with relatlimab, in PBMCs cocultured with THP-1 AML cells.
LAG-3 inhibitor 11 (10 uM) enhances AML cell killing, effectively potentiates immune responses against AML.
LAG-3 inhibitor 11 activates immune effector responses across both hematological and epithelial cancer models.

物理化学性质&存储条件

分子量	447.58
分子式	C30H29N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S)-N-([1,1'-biphenyl]-4-ylmethyl)-4-phenyl-1-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide

参考文献

1. Abdel-Rahman SA, et al. J Med Chem. 2025 Aug 20. doi: 10.1021/acs.jmedchem.5c00995.