LAF389 |CAS:270902-51-7 Probechem Biochemicals

Chemical Structure : LAF389

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LAF389 (LAF-389;LAF 389)

货号: PC-63316Not For Human Use, Lab Use Only.

LAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800 nM for MetAP-2, inhibits both MetAP1 and 2, potently inhibits HUVEC proliferation with IC50 of 20 nM.

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生物&药学活性

LAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800 nM for MetAP-2, inhibits both MetAP1 and 2, potently inhibits HUVEC proliferation with IC50 of 20 nM.
LAF389 demonstrates both antiproliferative and antiangiogenetic properties, and preclinical investigations showed a broad antitumour activity.

物理化学性质&存储条件

分子量	498.617
分子式	C25H42N2O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(3R,6S)-7-oxo-6-[[(E,2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enoyl]amino]azepan-3-yl] cyclohexanecarboxylate

参考文献

1. Kinder FR Jr, et al. J Med Chem. 2001 Oct 25;44(22):3692-9.

2. Towbin H, et al. J Biol Chem. 2003 Dec 26;278(52):52964-71.

3. Kim S, et al. Cancer Res. 2004 May 1;64(9):2984-7.

4. Dumez H, et al. Anticancer Drugs. 2007 Feb;18(2):219-25.

LAF389 (LAF-389;LAF 389)

生物&药学活性

物理化学性质&存储条件

参考文献

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LAF389 (LAF-389;LAF 389)

生物&药学活性

物理化学性质&存储条件

参考文献

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