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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-c-Myc-L755507
L755507

Chemical Structure : L755507

CAS No.: 159182-43-1

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L755507 (L 755507)

货号: PC-38661Not For Human Use, Lab Use Only.

L755507 is a potent, selective β3-adrenoceptor (β3-AR) agonist, exhibits robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors (pEC50=12.3), also effectively inhibits the c-Myc-MAX heterodimerization.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

L755507 is a potent, selective β3-adrenoceptor (β3-AR) agonist, exhibits robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors (pEC50=12.3), also effectively inhibits the c-Myc-MAX heterodimerization.
L755507 increases phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2) with pEC50 of 11.7, couples to both Gs and Gi to activate adenylate cyclase and MAPK signaling.
L755507 efficiently restricts the growth of diverse Myc-expressing cells with low micromolar IC50 values, decreases expression of c-Myc target genes.
L755507 binds to the c-Myc peptide and thereby stabilizes the helix–loop–helix conformation of the c-Myc transcription factor.

物理化学性质&存储条件

分子量 584.732
分子式 C30H40N4O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-4-(3-hexylureido)-N-(4-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide

参考文献

1. Sato M, et al. Mol Pharmacol. 2008 Nov;74(5):1417-28.

2. Hutchinson DS, et al. Br J Pharmacol. 2002 Apr;135(8):1903-14.

3. Singh A, et al. J Biol Chem. 2021 Jul;297(1):100903.

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