L6H21 | MD-2 inhibitor | Probechem Biochemicals

Chemical Structure : L6H21

CAS No.: 24533-47-9

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L6H21 (MD-2 inhibitor)

货号: PC-21724Not For Human Use, Lab Use Only.

L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex.

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10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex.
L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages with IC50 of 6.58 and 8.59 μM, respectively.
L6H21 inhibits EtOH + LPS-induced apoptosis and mitochondrial damage in RAW264.7 cells.
L6H21 attenuates EtOH + LPS-induced ROS formation and TLR4–NF-κB activation, and decreases NLRP3 inflammasome activation.
L6H21 (10 mg/kg, Oral gavage, daily) effectively inhibits EtOH + LPS-induced hepatic fat accumulation, hepatic steatosis and liver injury in vivo.

物理化学性质&存储条件

分子量	298.34
分子式	C18H18O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(2,3-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one

参考文献

1. Kong X, et al. Alcohol Clin Exp Res. 2019 Aug;43(8):1662-1671.

L6H21 (MD-2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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L6H21 (MD-2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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