L598 | PTP1B/TC-PTP inhibitor | Probechem Biochemicals

Chemical Structure : L598

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L598 (PTPN1/PTPN2 inhibitor)

货号: PC-25663Not For Human Use, Lab Use Only.

L598 is a potent, hosphotyrosine mimetic dual PTPN1/PTPN2 (PTP1B/TC-PTP) inhibitor with IC50 of 120 nM for both.

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生物&药学活性

L598 is a potent, hosphotyrosine mimetic dual PTPN1/PTPN2 (PTP1B/TC-PTP) inhibitor with IC50 of 120 nM for both.
L598 is a catalytic site inhibitor of PTPN1 that can inhibit PTPN2 at an equimolar concentration.
L598 enhances CTL responses against cancer cells.
L598 synergizes with PD-1 blockade to enhance anti-tumor immunity in vivo.

物理化学性质&存储条件

分子量	362.07
分子式	C12H7BrF2NO3P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((3-bromo-7-cyanonaphthalen-2-yl)difluoromethyl)phosphonic acid

参考文献

1. Perez-Quintero LA, et al. iScience. 2025 Sep 22;28(10):113610.

2. Yongxin Han, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3200-5.

L598 (PTPN1/PTPN2 inhibitor)

生物&药学活性

物理化学性质&存储条件

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L598 (PTPN1/PTPN2 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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