L-Moses dihydrochloride | PCAF/KAT2B inhibitor | Probechem Biochemicals

Chemical Structure : L-Moses dihydrochloride

CAS No.: 2079885-05-3

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L-Moses dihydrochloride (PCAF (KAT2B) inhibitor L-45)

货号: PC-20178Not For Human Use, Lab Use Only.

L-Moses dihydrochloride (L-45) is a potent, selective, and cell-active PCAF (KAT2B) bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4.

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5 mg	￥3980	In stock
10 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

L-Moses dihydrochloride (L-45) is a potent, selective, and cell-active PCAF (KAT2B) bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4.
L Moses disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, shows high selectivity for PCAF and GCN5 bromodomain (Kd=600 nM).
L Moses shows no observable cytotoxicity in PBMCs, good cell-permeability, and metabolic stability in human and mouse liver microsomes.

物理化学性质&存储条件

分子量	433.38
分子式	C21H26Cl2N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2S)-N1,N1-dimethyl-N2-(3-methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride

参考文献

1. Moustakim M, et al. Angew Chem Int Ed Engl. 2017 Jan 16;56(3):827-831.

L-Moses dihydrochloride (PCAF (KAT2B) inhibitor L-45)

生物&药学活性

物理化学性质&存储条件

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L-Moses dihydrochloride (PCAF (KAT2B) inhibitor L-45)

生物&药学活性

物理化学性质&存储条件

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