L-838417 | ⍺2,3,5 GABAA receptor PAM | Probechem Biochemicals

Chemical Structure : L-838417

CAS No.: 286456-42-6

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L-838417 (L-838,417)

货号: PC-24259Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2780	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

L-838417 (L-838,417) is a potent, ⍺2,3,5-selective GABAA receptor partial agonist/positive allosteric modulator (PAM) and antagonist at the α1, shows binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2 respectively.
L-838417 produces anxiolytic effects in adult rat, as indexed by a transformation of social avoidance into preference and an increase in social investigation.
L-838417 eliminates social avoidance, but has no anxiolytic effects on social investigation.

物理化学性质&存储条件

分子量	399.41
分子式	C19H19F2N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine

参考文献

1. McKernan RM, et al. Nat Neurosci. 2000 Jun;3(6):587-92. doi: 10.1038/75761.

2. Mikkelsen JD, et al. Eur J Pharmacol. 2005 Sep 20;519(3):223-30.

L-838417 (L-838,417)

生物&药学活性

物理化学性质&存储条件

参考文献

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L-838417 (L-838,417)

生物&药学活性

物理化学性质&存储条件

参考文献

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