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首页-小分子抑制剂&激动剂-GPCR-Neurokinin Receptor-L-732138
L-732138

Chemical Structure : L-732138

CAS No.: 148451-96-1

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L-732138 (L 732138, L732138)

货号: PC-60341Not For Human Use, Lab Use Only.

L-732138 is a potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.

规格 价格 库存 数量
5 mg ￥1780 In stock
10 mg ￥2580 In stock
25 mg ￥3980 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

L-732138 is a potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.
L-732138 displays >1,000-fold selectvity over the human NK-2 and NK-3 receptors.
L-732138 inhibits substance P-induced inositol phosphate synthesis, abolishes vagally-induced plasma exudation and significantly inhibits exogenous substance enhancement indcued by LPS.

物理化学性质&存储条件

分子量 472.39
分子式 C22H18F6N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester

参考文献

1. Cascieri MA, et al. J Biol Chem. 1994 Mar 4;269(9):6587-91.

2. MacLeod AM, et al. J Med Chem. 1994 Apr 29;37(9):1269-74.

3. Pedersen KE, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):319-25.

4. Kuo HP, et al. Br J Pharmacol. 1998 Oct;125(4):711-6.

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