L-368,899 hydrochloride

Chemical Structure : L-368,899 hydrochloride

CAS No.: 160312-62-9

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货号: PC-24224Not For Human Use, Lab Use Only.

L-368,899 hydrochloride is a potent, selective orally bioavailable, non-peptide oxytocin receptor (OTR, OXTR) antagonist with IC50 of 8.9 nM (rat uterus), and 26 nM (human uterus).

规格	价格	库存
1 mg	￥880	In stock
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

L-368,899 hydrochloride is a potent, selective orally bioavailable, non-peptide oxytocin receptor (OTR, OXTR) antagonist with IC50 of 8.9 nM (rat uterus), and 26 nM (human uterus).
L-368,899 inhibits OT-stimulated contractions of the isolated rat uterus (pA2 = 8.9) and in situ rat uterus (AD50 = 0.35 mg/kg after intravenous (i.v.) administration and 7.0 mg/kg after intraduodenal administration).

物理化学性质&存储条件

分子量	591.22
分子式	C26H43ClN4O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-amino-N-((1S,2S)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin-1-yl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide hydrochloride

参考文献

1. Williams PD, et al. J Med Chem. 1994 Mar 4;37(5):565-71.