L-368,899 | Oxytocin receptor antagonist | Probechem Biochemicals

Chemical Structure : L-368,899

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L-368,899 (L-368899)

货号: PC-24223Not For Human Use, Lab Use Only.

L-368,899 is a potent, selective orally bioavailable, non-peptide oxytocin receptor (OTR, OXTR) antagonist with IC50 of 8.9 nM (rat uterus), and 26 nM (human uterus).

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生物&药学活性

L-368,899 is a potent, selective orally bioavailable, non-peptide oxytocin receptor (OTR, OXTR) antagonist with IC50 of 8.9 nM (rat uterus), and 26 nM (human uterus).
L-368,899 inhibits OT-stimulated contractions of the isolated rat uterus (pA2 = 8.9) and in situ rat uterus (AD50 = 0.35 mg/kg after intravenous (i.v.) administration and 7.0 mg/kg after intraduodenal administration).

物理化学性质&存储条件

分子量	554.77
分子式	C26H42N4O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-Amino-N-((1S,2S)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin-1-yl)sulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide

参考文献

1. Williams PD, et al. J Med Chem. 1994 Mar 4;37(5):565-71.

L-368,899 (L-368899)

生物&药学活性

物理化学性质&存储条件

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L-368,899 (L-368899)

生物&药学活性

物理化学性质&存储条件

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