L-364373 |CAS:103342-82-1 Probechem Biochemicals

Chemical Structure : L-364373

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L-364373 (R-L3, L-364,373, L364373)

货号: PC-63221Not For Human Use, Lab Use Only.

L-364373 (R-L3) is a stereospecific activator of cardiac slowly activating delayed rectifier K+ current (IKs) and KV7.1 (KCNQ1) channels.

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生物&药学活性

L-364373 (R-L3) is a stereospecific activator of cardiac slowly activating delayed rectifier K+ current (IKs) and KV7.1 (KCNQ1) channels.
L-364373 significantly decreases APD50 and APD90 without significantly affecting other AP parameters at 0.1-1 uM, slows the rate of IKs deactivation and shifted the half-point of the isochronal (7.5 sec) activation curve for IKs by -16 mV at 0.1 uM and -24 mV at 1 uM.
L-364373 rescues pharmacologically induced long QT type 2 in isolated guinea pig cardiomyocytes.

物理化学性质&存储条件

分子量	397.453
分子式	C25H20FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one

参考文献

1. Salata JJ, et al. Mol Pharmacol. 1998 Jul;54(1):220-30.

2. Magyar J, et al. Naunyn Schmiedebergs Arch Pharmacol.

3. Nissen JD, et al. J Cardiovasc Pharmacol. 2009 Aug;54(2):169-77.

4. Corici C, et al. Can J Physiol Pharmacol. 2013 Aug;91(8):586-92.

L-364373 (R-L3, L-364,373, L364373)

生物&药学活性

物理化学性质&存储条件

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询单

L-364373 (R-L3, L-364,373, L364373)

生物&药学活性

物理化学性质&存储条件

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