L-257 |CAS 877120-88-2 Probechem Biochemicals

Chemical Structure : L-257

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L-257 (DDAH1 inhibitor L257)

货号: PC-36015Not For Human Use, Lab Use Only.

L-257 (DDAH-1 inhibitor L-257) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM, Ki of 13 uM.

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生物&药学活性

L-257 (DDAH-1 inhibitor L-257) is a selective, competitive DDAH1 inhibitor with IC50 of <25 uM, Ki of 13 uM.
L-257 shows no direct inhibitory activity against NO synthase or effects on endothelium-denuded vessels.
L-257 impairs vascular homeostasis, improves survival, haemodynamics and organ function in experimental septic shock.

物理化学性质&存储条件

分子量	232.284
分子式	C9H20N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N5-[Imino[(2-methoxyethyl)amino]methyl]-L-ornithine

参考文献

1. Nandi M, et al. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2589-97.

2. Wang Z, et al. Biochem J. 2014 Jun 1;460(2):309-16.

3. Rossiter S, et al. J Med Chem. 2005 Jul 14;48(14):4670-8.

4. Leiper J, et al. Nat Med. 2007 Feb;13(2):198-203.

L-257 (DDAH1 inhibitor L257)

生物&药学活性

物理化学性质&存储条件

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L-257 (DDAH1 inhibitor L257)

生物&药学活性

物理化学性质&存储条件

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