L-054,264 | SST2 agonist | Probechem Biochemicals

Chemical Structure : L-054,264

CAS No.: 208706-12-1

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L-054,264 (L-054264)

货号: PC-23186Not For Human Use, Lab Use Only.

L-054,264 is a potent, selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist with Ki of 1.6 nM, >1000-fold selective over other somatostatin receptor subtypes.

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生物&药学活性

L-054,264 is a potent, selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist with Ki of 1.6 nM, >1000-fold selective over other somatostatin receptor subtypes.
L-054,264 shows full agonism on sst2 in the inhibition of forskolin-stimulated accumulation of cAMP with an IC50 of 2 nM.
L-054,264 also inhibits the release of growth hormone in the rat pituitary assay with IC50 of 6 nM.

物理化学性质&存储条件

分子量	539.72
分子式	C33H41N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1R)-2-[[[3-(Aminomethyl)cyclohexyl]methyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]spiro[1H-indene-1,4′-piperidine]-1′-carboxamide

参考文献

1. Yang L, et al. J Med Chem. 1998 Jun 18;41(13):2175-9.

L-054,264 (L-054264)

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L-054,264 (L-054264)

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物理化学性质&存储条件

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