L-006235 |CAS:294623-49-7 Probechem Biochemicals

Chemical Structure : L-006235

CAS No.: 294623-49-7

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L-006235 (L006235;L 006235;CRA-013783;CRA 013783;L-235)

货号: PC-60641Not For Human Use, Lab Use Only.

L-006235 (L-235, CRA-013783) is a potent, selective, orally bioavailable cathepsin K inhibitor with IC50 of 0.25 nM, displays >4,000-fold selectivity over cathepsins B, L and S.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

L-006235 (L-235, CRA-013783) is a potent, selective, orally bioavailable cathepsin K inhibitor with IC50 of 0.25 nM, displays >4,000-fold selectivity over cathepsins B, L and S.
L-006235 exhibits an IC50 of 28 nM at cellular level in human osteoclasts, >1,000-fold selectivity against cathepsin S.
L-006235 reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice.

物理化学性质&存储条件

分子量	466.6
分子式	C24H30N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO
Chemical Name/SMILES	N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide

参考文献

1. Palmer JT, et al. J Med Chem. 2005 Dec 1;48(24):7520-34.

2. Falgueyret JP, et al. J Med Chem. 2005 Dec 1;48(24):7535-43.

3. Svelander L, et al. Eur J Pharmacol. 2009 Jun 24;613(1-3):155-62.

4. Hayami T, et al. Bone. 2012 Jun;50(6):1250-9.

L-006235 (L006235;L 006235;CRA-013783;CRA 013783;L-235)

生物&药学活性

物理化学性质&存储条件

参考文献

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L-006235 (L006235;L 006235;CRA-013783;CRA 013783;L-235)

生物&药学活性

物理化学性质&存储条件

参考文献

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