欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -Kuwanon C
Kuwanon C

Chemical Structure : Kuwanon C

CAS No.: 62949-79-5

加入收藏

Kuwanon C (Mulberrin)

货号: PC-25519Not For Human Use, Lab Use Only.

Kuwanon C (KWN-C, Mulberrin) is an effective inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with IC50 of 1.8 uM, also inhibits SIRT1 activity via targeting activity of the TGF-β1-Smad2/3-JNK1 signaling pathway.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Kuwanon C (KWN-C, Mulberrin) is an effective inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with IC50 of 1.8 uM, also inhibits SIRT1 activity via targeting activity of the TGF-β1-Smad2/3-JNK1 signaling pathway.
KWN-C suppressed pSmad2/3–JNK1 levels, which subsequently abrogated the phosphorylation of SIRT1S27 and SIRT1S47.
KWN-C decreases KRASMut activity via reducing SIRT1 activity and enhancing the acetylation of KRASMut.
KWN-C synergistically decreased KRASMut lung cancer proliferation combined with Cisplatin and Pemetrexed.
KWN-C synergistically reduces tumor burden in lung orthotropic models bearing KRAS G12C combined with Cisplatin and Pemetrexed.

物理化学性质&存储条件

分子量 422.48
分子式 C25H26O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methylbut-2-en-1-yl)-4H-chromen-4-one

参考文献

1. Wen F, et al. Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol. 2016;54(2):293-302.

2. Shin DH, et al. Exp Mol Med. 2025 Sep 12. doi: 10.1038/s12276-025-01536-8.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: