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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cdc2-like Kinase (CLK)-KuWal151
KuWal151

Chemical Structure : KuWal151

CAS No.: 2341841-06-1

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KuWal151 (KuWal 151)

货号: PC-63470Not For Human Use, Lab Use Only.

KuWal151 is a potent, selective cdc2-like kinase (CLK) inhibitor with IC50 of 88/510/28 nM for CLK1/2/4, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KuWal151 is a potent, selective cdc2-like kinase (CLK) inhibitor with IC50 of 88/510/28 nM for CLK1/2/4, respectively.
    KuWal151 shows no activity against CLK3 (IC50>10 uM), exhibits selectivity versus DYRK1A and other DYRK kinases.
    KuWal151 displays a potent antiproliferative activity in an array of cultured cancer cell lines (HCT-116 cell GI50=191 nM).

    物理化学性质&存储条件

    分子量 282.727
    分子式 C16H11ClN2O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(3-chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one

    参考文献

    1. Walter A, et al. PLoS One. 2018 May 3;13(5):e0196761.

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