Kobe2602 | Ras inhibitor | Probechem Biochemicals

Chemical Structure : Kobe2602

CAS No.: 454453-49-7

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Kobe2602 (Kobe 2602)

货号: PC-21604Not For Human Use, Lab Use Only.

Kobe2602 is a small-molecule Ras inhibitor that display antitumor activity by interfering with Ras·GTP-effector interaction, inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 149 uM.

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25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2880	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Kobe2602 is a small-molecule Ras inhibitor that display antitumor activity by interfering with Ras·GTP-effector interaction, inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 149 uM.
Kobe2602 (20 μM) efficiently inhibited the phosphorylation of MEK and ERK, downstream kinases of Raf in NIH 3T3 cells transiently expressing H-RasG12V.
Kobe2602 (20 μM) almost completely inhibited the proliferation of H-rasG12V–transformed NIH 3T3 cells in the presence of 2% FBS (IC50=2 uM).
Kobe2602 (80 mg/kg) exhibited antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-rasG12V gene by oral administration.

物理化学性质&存储条件

分子量	419.31
分子式	C14H9F4N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-Dinitro-4-(trifluoromethyl)phenyl)-N-(4-fluorophenyl)hydrazine-1-carbothioamide

参考文献

1. Shima F, et al. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7.

2. Shima F, et al. Enzymes. 2013;34 Pt. B:1-23.

Kobe2602 (Kobe 2602)

生物&药学活性

物理化学性质&存储条件

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Kobe2602 (Kobe 2602)

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