Ki8751 | VEGFR-2 inhibitor | Probechem Biochemicals

Chemical Structure : Ki8751

CAS No.: 228559-41-9

加入收藏

Ki8751 (Ki 8751, Ki-8751)

货号: PC-42853Not For Human Use, Lab Use Only.

Ki8751 is a potent, selective and orally active VEGFR-2 inhibitor that inhibits VEGFR-2 phosphorylation with IC50 of 0.6 nM.

规格	价格	库存
5 mg (Free Sample)	￥280	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Ki8751 is a potent, selective and orally active VEGFR-2 inhibitor that inhibits VEGFR-2 phosphorylation with IC50 of 0.6 nM.
Ki8751 also inhibits PDGFR family members such as PDGFRα and c-Kit at 67 nM and 40 nM, does not have any inhibitory activity against other kinases such as EGFR, HGFR, InsulinR (IC50>10 uM).
Ki8751 suppressed the growth of the VEGF-stimulated HUVEC on nanomolar level, shows significant antitumor activity against human tumor xenografts such as glioma, stomach carcinoma), lung carcinoma, colon carcinoma and melanoma in nude mice.

物理化学性质&存储条件

分子量	469.4126
分子式	C24H18F3N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥92mg/mL; Water: <1.2mg/mL; Ethanol: <1.2mg/mL
Chemical Name/SMILES	Urea, N-(2,4-difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]-

参考文献

1. Kubo K, et al. J Med Chem. 2005 Mar 10;48(5):1359-66.

2. Arao T, et al. Anticancer Res. 2011 Sep;31(9):2787-96.

3. Hasan MR, et al. Int J Cancer. 2011 Nov 1;129(9):2115-23.

Ki8751 (Ki 8751, Ki-8751)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Ki8751 (Ki 8751, Ki-8751)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.