Ki26894 | TβR-I kinase inhibitor | Probechem Biochemicals

Chemical Structure : Ki26894

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Ki26894 (Ki 26894)

货号: PC-49752Not For Human Use, Lab Use Only.

Ki26894 (Ki 26894) is a small molecule TGF-beta type I receptor (TbetaR-I) kinase inhibitor, inhibits TGF-β-induced transcriptional activation in MDA-231-D-TβFluc/Rluc cells with IC50 of 0.49 uM.

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生物&药学活性

Ki26894 (Ki 26894) is a small molecule TGF-beta type I receptor (TbetaR-I) kinase inhibitor, inhibits TGF-β-induced transcriptional activation in MDA-231-D-TβFluc/Rluc cells with IC50 of 0.49 uM.
Ki26894 reduces the level of TGF-β-induced transcription to basal level at 3 uM in MDA-231-D-TβFluc/Rluc cells.
Ki26894 decreases motility and invasion of MDA-231-D cells induced by TGF-β.
Ki26894 inhibits TGF-β-induced transcription of PAI-1, PTHrP and IL-11 in MDA-231-D cells.
Ki26894 prevents metastasis of MDA-231-D cells and prolongs the survival of MDA-231-D-bearing mice.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Ehata S, et al. Cancer Sci. 2007 Jan;98(1):127-33.

2. Shinto O, et al. Br J Cancer. 2010 Mar 2;102(5):844-51.

3. Shinto O, et al. Cancer Sci. 2010 Aug;101(8):1846-52.

Ki26894 (Ki 26894)

生物&药学活性

物理化学性质&存储条件

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Ki26894 (Ki 26894)

生物&药学活性

物理化学性质&存储条件

参考文献

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