Ki20227 |CAS:623142-96-1 Probechem Biochemicals

Chemical Structure : Ki20227

CAS No.: 623142-96-1

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Ki20227 (Ki 20227;Ki-20227)

货号: PC-42568Not For Human Use, Lab Use Only.

Ki20227 is a potent, selective, orally active c-Fms inhibitor with IC50 of 2 nM.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

Ki20227 is a potent, selective, orally active c-Fms (CSF1R) inhibitor with IC50 of 2 nM.
Ki20227 weakly inhibits KDR, c-Kit, and PDGFRβ with IC50 of 12, 451, and 217 nM, respectively, no activty against Flt-3, c-Src, Fyn, EGFR, FGFR2, Met, Btk, PKA, and PKCα (IC50>1,000 nM).
Ki20227 inhibits the M-CSF-dependent cell growth, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.

物理化学性质&存储条件

分子量	480.5362
分子式	C24H24N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 7.2 mg/mL
Chemical Name/SMILES	Urea, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]-

参考文献

1. Ohno H, et al. Mol Cancer Ther. 2006 Nov;5(11):2634-43.

2. Ohno H, et al. Eur J Immunol. 2008 Jan;38(1):283-91.

3. Uemura Y, et al. J Neuroimmunol. 2008 Mar;195(1-2):73-80.

Ki20227 (Ki 20227;Ki-20227)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ki20227 (Ki 20227;Ki-20227)

生物&药学活性

物理化学性质&存储条件

参考文献

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