Ki19003 | CCR3 antagonist | Probechem Biochemicals

Chemical Structure : Ki19003

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Ki19003 (Ki 19003)

货号: PC-20728Not For Human Use, Lab Use Only.

Ki19003 (Ki 19003) is a potent, specific CCR3 antagonist, inhibits the CCL11-induced migration of CCR3-expressing L1.2 cells with IC50 of 20 nM.

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生物&药学活性

Ki19003 (Ki 19003) is a potent, specific CCR3 antagonist, inhibits the CCL11-induced migration of CCR3-expressing L1.2 cells with IC50 of 20 nM.
Ki19003 does not inhibit CCL2- or CCL19-induced migration of CCR2- or CCR7-receptor-expressing cells even at 10 uM.
Ki19003 inhibits CCL11-induced migration of bone marrow–derived eosinophilic granulocytes in a concentration-dependent manner, shows no
cytotoxicity against the cells at 10 uM.
Ki19003 (3 or 10 mg/kg, oral) significantly inhibited the increase in the number of eosinophils in bronchoalveolar lavage fluid (BALF) of sensitized BALB/c mice.
Ki19003 also inhibited the increased production of transforming growth factor-beta1 in BALF and the amount of hydroxyproline in the lungs in a dose-dependent manner.
Ki19003 significantly attenuated allergen-induced subepithelial and peribronchial fibrosis.

物理化学性质&存储条件

分子量	528.90
分子式	C25H32Cl3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)CCCN(C(C1=CC=C(Cl)C=C1)C)CCCCCNC(NCC2=CC=C(Cl)C=C2Cl)=O

参考文献

1. Masato Komai, et al. J Pharmacol Sci. 2010;112(2):203-13.

Ki19003 (Ki 19003)

生物&药学活性

物理化学性质&存储条件

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Ki19003 (Ki 19003)

生物&药学活性

物理化学性质&存储条件

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