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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-Ketanserin
Ketanserin

Chemical Structure : Ketanserin

CAS No.: 74050-98-9

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Ketanserin (R41468)

货号: PC-42653Not For Human Use, Lab Use Only.

Ketanserin (R41468) is a high-affinity, non-selective antagonist of 5-HT2 receptor with Ki of 2-3 nM for 5-HT2A and 28 nM for 5-HT2C.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ketanserin (R41468) is a high-affinity, non-selective antagonist of 5-HT2 receptor with Ki of 2-3 nM for 5-HT2A and 28 nM for 5-HT2C.
Ketanserin (R41468) also has a high affinity antagonist for the H1 receptor (Ki= 2 nM) and α1-adrenergic receptor (Ki=40 nM).
Ketanserin (R41468) is an antihypertensive agent.

物理化学性质&存储条件

分子量 395.4268
分子式 C22H22FN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 8 mg/mL
Chemical Name/SMILES

2,4(1H,3H)-Quinazolinedione, 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-

参考文献

1. Creed-Carson M, et al. Behav Brain Res. 2011 Jun 1;219(2):273-9.

2. Catafau AM, et al. J Cereb Blood Flow Metab. 2010 May;30(5):985-93.

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