Keap1-Nrf2 inhibitor 6K

Chemical Structure : Keap1-Nrf2 inhibitor 6K

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货号: PC-28166Not For Human Use, Lab Use Only.

Keap1-Nrf2 inhibitor 6K is a small molecule inhibitor of Keap1-Nrf2 interaction, exhibits high Keap1-binding affinity (KD2 values=210 nM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Keap1-Nrf2 inhibitor 6K is a small molecule inhibitor of Keap1-Nrf2 interaction, exhibits high Keap1-binding affinity (KD2 values=210 nM).
Keap1-Nrf2 inhibitor 6K markedly improves renal function, suppresses OS and ferroptosis, and upregulates adaptive repair-related genes and downregulates maladaptive repair-related genes in bIRI mice.
Keap1-Nrf2 inhibitor 6K activated the Nrf2-GPX4 axis, thereby alleviated RSL3-induced suppression of GPX4 expression, reduced reactive oxygen species (ROS) accumulation and lipid peroxidation, and mitigated ferroptosis in human kidney-2 (HK-2) cells.
Keap1-Nrf2 inhibitor 6K significantly delayed fibrosis progression in bIRI and unilateral ureteral obstruction (UUO) models.

物理化学性质&存储条件

分子量	765.90
分子式	C36H43N7O8S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(N-(2-amino-2-oxoethyl)-N-(4-((N-(2-amino-2-oxoethyl)-4-methoxyphenyl)sulfonamido)naphthalen-1-yl)sulfamoyl)phenyl)-3-(4-ethylpiperazin-1-yl)propanamide

参考文献

1. Wang Y, et al. Redox Biol. 2026 Sep 2;97:104374.

2. Liu G, et al. J Med Chem. 2022 Jun 23;65(12):8289-8302.