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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-Keap1-Nrf2 inhibitor 57
Keap1-Nrf2 inhibitor 57

Chemical Structure : Keap1-Nrf2 inhibitor 57

CAS No.:

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Keap1-Nrf2 inhibitor 57

货号: PC-23226Not For Human Use, Lab Use Only.

Keap1-Nrf2 inhibitor 57 is a higly potent, noncovalent Keap1-Nrf2 inhibitor with Ki of 13 nM in FP assays, binds the Keap1 Kelch domain with excellent selectivity over close homologues from the Kelch-like protein family.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Keap1-Nrf2 inhibitor 57 is a higly potent, noncovalent Keap1-Nrf2 inhibitor with Ki of 13 nM in FP assays, binds the Keap1 Kelch domain with excellent selectivity over close homologues from the Kelch-like protein family.

物理化学性质&存储条件

分子量 596.63
分子式 C32H25FN4O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-((3-Cyano-4-fluorophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-(9-methyl-9H-carbazole-4-carboxamido)acetic Acid

参考文献

1. Qin Y, et al. J Med Chem. 2024 Oct 17. doi: 10.1021/acs.jmedchem.4c01221.

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