Keap1-Nrf2 inhibitor 25

Chemical Structure : Keap1-Nrf2 inhibitor 25

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货号: PC-20558Not For Human Use, Lab Use Only.

Keap1-Nrf2 inhibitor 25 is a potent, orally bioavailable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with IC50 of 89 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Keap1-Nrf2 inhibitor 25 is a potent, orally bioavailable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with IC50 of 89 nM.
Keap1-Nrf2 inhibitor 25 (3-30 mg/kg p.o.) demonstrated dose-dependent manner for up-regulation of the antioxidant protein heme oxigenase-1 (HO-1) in rat kidneys.

物理化学性质&存储条件

分子量	383.46
分子式	C23H26FNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)[C@H](C)[C@H](NC([C@@H](F)C1=CC=C2CCCCC2=C1)=O)C3=CC=C(C)C=C3

参考文献

1. Kazuki Otake, et al. ACS Medicinal Chemistry Letter. April 7, 2023