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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGFβ-Smad-Kartogenin
Kartogenin

Chemical Structure : Kartogenin

CAS No.: 4727-31-5

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Kartogenin (KGN)

货号: PC-26809Not For Human Use, Lab Use Only.

Kartogenin (KGN) is a small molecule stimulator of collagen synthesis of mesenchymal stem cells (MSCs), binds filamin A and disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program promotes chondrocyte differentiation with EC50 of 100 nM.

规格 价格 库存 数量
25 mg ￥880 In stock
50 mg ￥1280 In stock
100 mg ￥1980 In stock
250 mg ￥3280 In stock
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Kartogenin (KGN) is a small molecule stimulator of collagen synthesis of mesenchymal stem cells (MSCs), binds filamin A and disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program promotes chondrocyte differentiation with EC50 of 100 nM.
Kartogenin (KGN) shows chondroprotective effects in vitro and in osteoarthritis (OA) animal models.
Kartogenin (KGN) stimulate collagen synthesis of mesenchymal stem cells (MSCs).
Kartogenin (KGN) also is a potent stimulator of limb skeletal growth, facilitates joint formation by promoting interzone compaction and lubricin/Prg4 expression, and stimulates the activity of key signaling factors, including TGFβ superfamily members.

物理化学性质&存储条件

分子量 317.34
分子式 C20H15NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-([1,1'-Biphenyl]-4-ylcarbamoyl)benzoic acid

参考文献

1. Johnson K, et al. Science. 2012 May 11;336(6082):717-21.

2. Wang J, et al. Biochem Biophys Res Commun. 2014 Jul 18;450(1):568-74.

3. Decker RS, et al. Dev Biol. 2014 Nov 15;395(2):255-67.

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