Kaitocephalin | iGluR antagonist | Probechem Biochemicals

Chemical Structure : Kaitocephalin

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Kaitocephalin (PF 1191)

货号: PC-61708Not For Human Use, Lab Use Only.

Kaitocephalin (PF 1191) is a non-selective ionotropic glutamate receptor (iGluR) antagonist, the first discovered natural toxin with protective properties against excitotoxic-death of cultured neurons induced by NMDA or AMPA/kainate receptors.

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生物&药学活性

Kaitocephalin (PF 1191) is a non-selective ionotropic glutamate receptor (iGluR) antagonist, the first discovered natural toxin with protective properties against excitotoxic-death of cultured neurons induced by NMDA or AMPA/kainate receptors.
Kaitocephalin is a more potent antagonist of NMDA receptors (IC50= 75 nM) than of AMPA receptors from cerebral cortex (IC50=242 nM) and from homomeric GluR3 subunits (IC50=502 nM).
Kaitocephalin shows neuroprotective properties, and protects neurons by inhibiting excitotoxicity.

物理化学性质&存储条件

分子量	494.28
分子式	C18H21Cl2N3O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5R)-2-[(1S,2R)-2-Amino-2-carboxy-1-hydroxyethyl]-5-{(2S)-2-carboxy-2-[(3,5-dichloro-4-hydroxybenzoyl)amino]ethyl}-L-proline

参考文献

1. Ma D, et al. J Am Chem Soc. 2001 Oct 3;123(39):9706-7.

2. Shin-Ya K, et al. Biosci Biotechnol Biochem. 2005 May;69(5):867-72.

3. Limon A, et al. ACS Chem Neurosci. 2010 Mar 17;1(3):175-181.

Kaitocephalin (PF 1191)

生物&药学活性

物理化学性质&存储条件

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Kaitocephalin (PF 1191)

生物&药学活性

物理化学性质&存储条件

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