KYA1797K |CAS:1956356-56-1 Probechem Biochemicals

Chemical Structure : KYA1797K

CAS No.: 1956356-56-1

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KYA1797K (KYA-1797K)

货号: PC-70092Not For Human Use, Lab Use Only.

KYA1797K is a derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

KYA-1797K is a derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling.
KYA-1797K dose-dependently decreases Wnt3a-CM-induced TOPflash reporter activation with IC50 of 0.75 uM.
KYA-1797K is more effectively reduces the levels of both β-catenin and pan-Ras as well as the activities of ERK and Akt in SW480 cells.
KYA-1797K binds to Axin (Kd to WT axin-RGS=0.29 uM) and destabilizes b-catenin and Ras; inhibits growth of CRC cells with GI50 of 4-5 uM.
KYA-1797K suppresses the tumors induced by APC and KRAS mutations in tumor xenograft mice (25 mg/kg, i.p.).

物理化学性质&存储条件

分子量	442.501
分子式	C17H11KN2O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	potassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate

参考文献

1. Cha PH, et al. Nat Chem Biol. 2016 Aug;12(8):593-600.

2. Cha PH, et al. BMB Rep. 2016 Sep;49(9):455-6.

KYA1797K (KYA-1797K)

生物&药学活性

物理化学性质&存储条件

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KYA1797K (KYA-1797K)

生物&药学活性

物理化学性质&存储条件

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