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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -KY386
KY386

Chemical Structure : KY386

CAS No.: 2787598-01-8

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KY386 (KY 386, KY-386)

货号: PC-21245Not For Human Use, Lab Use Only.

KY386 is a potent, selective inhibitor of RNA helicase DHX33 with IC50 of 19 nM.

规格 价格 库存 数量
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KY386 is a potent, selective inhibitor of RNA helicase DHX33 with IC50 of 19 nM.
KY386 potently inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.
KY386 has little inhibitory effect toward other RNA helicases include DDX6, DHX15, DDX21, DHX32, DHX35, DHX40 and DDX59.
KY386 shows potent anti-cancer activity and moderate metabolic stability.

物理化学性质&存储条件

分子量 405.48
分子式 C21H19N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3-cyano-5-methylthiophen-2-yl)-N-(6-methoxy-1H-benzo[d]imidazol-2-yl)-2,5-dimethyl-1H-pyrrole-3-carboxamide

参考文献

1. Wang Y, et al. Bioorg Med Chem Lett. 2023 Oct 12:129505.

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