KY-226 |CAS:1621673-53-7 Probechem Biochemicals

Chemical Structure : KY-226

CAS No.: 1621673-53-7

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KY-226 (KY226)

货号: PC-35377Not For Human Use, Lab Use Only.

KY-226 (KY226) is a potent, allosteric, orally active inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 uM (human PTP1B), does not exhibit PPARγ agonist activity.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KY-226 (KY226) is a potent, allosteric, orally active inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 uM (human PTP1B), does not exhibit PPARγ agonist activity.
KY-226 shows no effects on adipocyte differentiation in rodent preadipocytes at 10 uM, bot not the PPARγ agonist pioglitazone.
KY-226 increases the phosphorylated insulin receptor (pIR) produced by insulin in human hepatoma-derived cells (HepG2) at 0.310 uM,.
KY-226 ignificantly reduces plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain in db/db mice,.
KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling.

物理化学性质&存储条件

分子量	481.669
分子式	C27H31NO3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide

参考文献

1. Ito Y, et al. J Pharmacol Sci. 2018 May;137(1):38-46.

2. Sun M, et al. Brain Res. 2018 Sep 1;1694:1-12.

KY-226 (KY226)

生物&药学活性

物理化学性质&存储条件

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KY-226 (KY226)

生物&药学活性

物理化学性质&存储条件

参考文献

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