KY-05009 | TNIK inhibitor | Probechem Biochemicals

Chemical Structure : KY-05009

CAS No.: 1228280-29-2

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KY-05009 (KY05009, KY 05009)

货号: PC-36009Not For Human Use, Lab Use Only.

KY-05009 (KY05009) is a potent, ATP-competitive inhibitor of Traf2- and Nck-interacting kinase (TNIK) with Ki of 100 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

KY-05009 (KY05009) is a potent, ATP-competitive inhibitor of Traf2- and Nck-interacting kinase (TNIK) with Ki of 100 nM.
KY-05009 (KY05009) significantly and strongly inhibited the TGF-β-activated EMT through the attenuation of Smad and non-Smad signaling pathways, including the Wnt, NF-κB, FAK-Src-paxillin-related focal adhesion, and MAP kinases (ERK and JNK) signaling pathways in A549 cells.
KY-05009 (KY05009) synergistically inhibited IL-6-stimulated proliferation and induced apoptosis through the inhibition of Wnt signaling in MM cells when combined Dovitinib.

物理化学性质&存储条件

分子量	352.412
分子式	C18H16N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide

参考文献

1. Kim J, et al. PLoS One. 2014 Oct 22;9(10):e110180.

2. Lee Y, et al. Oncotarget. 2017 Jun 20;8(25):41091-41101.

3. Yamada T, et al. (2010) TNIK inhibitor and its use. US2010/0216795.

KY-05009 (KY05009, KY 05009)

生物&药学活性

物理化学性质&存储条件

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KY-05009 (KY05009, KY 05009)

生物&药学活性

物理化学性质&存储条件

参考文献

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