KY-02327 |CAS:2093407-25-9 Probechem Biochemicals

Chemical Structure : KY-02327

CAS No.: 2093407-25-9

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KY-02327 (KY02327)

货号: PC-63512Not For Human Use, Lab Use Only.

KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog.

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5 mg	￥3580	In stock
10 mg	￥5280	In stock
25 mg	￥7880	In stock
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog.
KY-02327 is more stable by 2.3-fold and 1.3-fold than KY-02061 in rat liver microsomes and in human hepatocytes, respectively.
KY-02327 shows enhanced effect on induction of ALP activity of osteoblast cells compared with KY-02061.
KY-02327 activates the Wnt/β-catenin pathway, promotes osteoblast differentiation, and rescues BMD, bone volume, and trabecular bone structures in variectomized (OVX) mouse model.

物理化学性质&存储条件

分子量	373.453
分子式	C20H27N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 5-hydroxy-1-(2-oxo-2-((2-(piperidin-1-yl)ethyl)amino)ethyl)-1H-indole-2-carboxylate

参考文献

1. Kim HY, et al. EMBO Mol Med. 2016 Apr 1;8(4):375-87.

KY-02327 (KY02327)

生物&药学活性

物理化学性质&存储条件

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KY-02327 (KY02327)

生物&药学活性

物理化学性质&存储条件

参考文献

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