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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Dishevelled-KY-02061
KY-02061

Chemical Structure : KY-02061

CAS No.: 2093406-88-1

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KY-02061 (KY02061)

货号: PC-63513Not For Human Use, Lab Use Only.

KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay.
    KY-02061 increases the activation of the Wnt/β-catenin pathway in a dose-dependent manner as revealed by the TOPflash reporter assay.
    ALP activity also increased in a dose‐dependent manner in KY-02061-treated primary osteoblast cells.
    KY-02061 increases levels of Runx2, an osteoblast differentiation marker, and β-catenin

    物理化学性质&存储条件

    分子量 445.486
    分子式 C22H23NO7S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl 1-(2-ethoxy-2-oxoethyl)-5-(tosyloxy)-1H-indole-2-carboxylate

    参考文献

    1. Kim HY, et al. EMBO Mol Med. 2016 Apr 1;8(4):375-87.

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