KX2-391 mesylate |CAS:1080645-95-9 Probechem Biochemicals

Chemical Structure : KX2-391 mesylate

CAS No.: 1080645-95-9

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KX2-391 mesylate (KX01 Mesylate)

货号: PC-42539Not For Human Use, Lab Use Only.

A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor.

规格	价格	库存
10 mg	￥960	In stock
50 mg	￥3760	In stock
100 mg	￥6400	In stock

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生物&药学活性

A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor; inhibits c-Src kinase with GI50s of 1.34 uM and 2.30 μM in NIH3T3/c-Src527F and SYF/c-Src527F cells, respectively; causes microtubule disruption in tumor cells; orally active.

Solid Tumors

Phase 2 Clinical

物理化学性质&存储条件

分子量	527.6324
分子式	C27H33N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 57 mg/mL
Chemical Name/SMILES	2-Pyridineacetamide, 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-, methanesulfonate (1:1)

参考文献

1. Fallah-Tafti A, et al. Eur J Med Chem. 2011 Oct;46(10):4853-8.

2. Anbalagan M, et al. Mol Cancer Ther. 2012 Sep;11(9):1936-47.

3. Liu T, et al. Clin Cancer Res. 2013 Dec 1;19(23):6532-43.

KX2-391 mesylate (KX01 Mesylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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KX2-391 mesylate (KX01 Mesylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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