KX2-361 |CAS:897016-26-1 Probechem Biochemicals

Chemical Structure : KX2-361

CAS No.: 897016-26-1

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KX2-361 (KX-2361, KX-02)

货号: PC-63531Not For Human Use, Lab Use Only.

KX2-361 (KX 02) is a potent, orally active dual Src signaling/tubulin polymerization inhibitor, KX2-361 is a non-ATP competitive Src inhibitor, demonstrates broad anti-tumor activity both in vitro and in vivo.

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5 mg	￥2280	In stock
10 mg	￥3680	In stock
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生物&药学活性

KX2-361 (KX 02) is a potent, orally active dual Src signaling/tubulin polymerization inhibitor, KX2-361 is a non-ATP competitive Src inhibitor, demonstrates broad anti-tumor activity both in vitro and in vivo.

KX2-361 binds to tubulin and disrupts microtubule architecture in cells.

KX2-361 (200 nM) reduced autophosphorylation of Src at tyrosine 416, consistent with reduced Src signaling activity.

KX2-361 (5 µM) inhibits the in vitro assembly of tubulin polymers.

KX2-361 disrupts the microtubule network resulting in altered morphology, loss of microtubule integrity, and a general reduction in cell size in intact GL261 cells.

KX2‑361 promotes cell cycle arrest and apoptosis.

KX2‑361 significantly delays progression of orthotopic GL261 brain tumors and produces long‑term survival.

物理化学性质&存储条件

分子量	405.473
分子式	C24H24FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl)acetamide

参考文献

1. Smolinski MP, et al. J Med Chem. 2018 Apr 17. doi: 10.1021/acs.jmedchem.8b00164.
2 Ciesielski MJ, et al. J Neurooncol. 2018 Dec;140(3):519-527.

KX2-361 (KX-2361, KX-02)

生物&药学活性

物理化学性质&存储条件

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KX2-361 (KX-2361, KX-02)

生物&药学活性

物理化学性质&存储条件

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