KWR095 | WRN inhibitor | Probechem Biochemicals

Chemical Structure : KWR095

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KWR095 (KWR-095)

货号: PC-24056Not For Human Use, Lab Use Only.

KWR095 is a novel potent inhibitor of Werner protein WRN with IC50 of 32 nM (WRN ATPase).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KWR095 is a novel potent inhibitor of Werner protein WRN with IC50 of 32 nM (WRN ATPase).
KWR095 is more potent than HRO761 on WRN ATPase activity, but slightly weaker effect on WNR helicase activity.
KWR095 exhibits a GI50 value of 0.193 μM in SW48 cells.
KWR095 induces WRN degradation in the MSI-H CRC cells, SW48 and HCT116, but caused no degradation in the MSS CRC cell line, SW620. KWR095 (40 mg/kg, oral, daily) exhibits significant antitumor effects in SW48 cell xenograft model mice.

物理化学性质&存储条件

分子量	710.12
分子式	C33H31ClF3N9O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-(4-(1H-pyrrolo[2,3-c]pyridine-7-carbonyl)piperazin-1-yl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide

参考文献

1. Moon B, et al. Bioorg Med Chem Lett. 2025 Feb 14:130141.

KWR095 (KWR-095)

生物&药学活性

物理化学性质&存储条件

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KWR095 (KWR-095)

生物&药学活性

物理化学性质&存储条件

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