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首页-抗体和重组蛋白-Biosimilar Antibody-KWAR23
KWAR23

Chemical Structure : KWAR23

CAS No.:

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KWAR23 (Anti-human SIRPα mAb, human IgG1-Kappa)

货号: PC-Ab1111Not For Human Use, Lab Use Only.

KWAR23 is a monoclonal anti-human SIRPα antibody that binds to human SIRPα with high affinity, blocks the interaction of CD47 on one cell with SIRPα on a phagocytic cell. KWAR23 induces human macrophage-dependent phagocytosis in human tumor-derived cell lines, restores chemokine secretion in human macrophages in vitro, greatly augments myeloid cell-dependent killing of a collec-tion of hematopoietic and nonhematopoietic human tumor-derived cell lines..

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

KWAR23 is a monoclonal anti-human SIRPα antibody that binds to human SIRPα with high affinity, blocks the interaction of CD47 on one cell with SIRPα on a phagocytic cell. KWAR23 induces human macrophage-dependent phagocytosis in human tumor-derived cell lines, restores chemokine secretion in human macrophages in vitro, greatly augments myeloid cell-dependent killing of a collec-tion of hematopoietic and nonhematopoietic human tumor-derived cell lines.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

KWAR23; Anti-Human SIRPα; Anti-Human SIRP alpha; Anti-human Signal regulatory protein alpha; Anti-human SHPS-1; Anti-human SIRPA

参考文献

1. 1, Nan Guo Ring, et al. Proc Natl Acad Sci U S A. 2017 Dec 5; 114(49): E10578–E10585. 2, Gabriela Andrejeva, et al. J Immunol. 2021 Feb 15; 206(4): 712–721. 3, Xiao Jia, et al. Int J Biol Sci. 2021; 17(13): 3281–3287.

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