KW-2581 |CAS:284045-56-3 Probechem Biochemicals

Chemical Structure : KW-2581

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KW-2581 (KW2581)

货号: PC-61434Not For Human Use, Lab Use Only.

A novel potent, irreversible and orally active inhibitor of steroid sulfatase (STS) with IC50 of 13 nM in ZR-75-1 cells.

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生物&药学活性

A novel potent, irreversible and orally active inhibitor of steroid sulfatase (STS) with IC50 of 13 nM in ZR-75-1 cells; inhibits the E1S-stimulated growth of ZR-75-1 cells, reduces the expression of E1S-induced progesterone receptors at concentrations as low as 0.1 nM; causes tumor shrinkage in a mouse xenograft model.

Breast Cancer

Discontinued

物理化学性质&存储条件

分子量	460.633
分子式	C25H36N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(8S,9S,13S,14S)-17-[di(propan-2-yl)carbamoyl]-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-3-yl] sulfamate

参考文献

1. Ishida H, et al. Breast Cancer Res Treat. 2007 Aug;104(2):211-9.

2. Ishida H, et al. Breast Cancer Res Treat. 2007 Dec;106(2):215-27

3. Ishida H, et al. J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):17-22.

KW-2581 (KW2581)

生物&药学活性

物理化学性质&存储条件

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KW-2581 (KW2581)

生物&药学活性

物理化学性质&存储条件

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