KW-2478 |CAS:819812-18-5 Probechem Biochemicals

Chemical Structure : KW-2478

CAS No.: 819812-18-5

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KW-2478 (KW2478;KW 2478)

货号: PC-61250Not For Human Use, Lab Use Only.

KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3580	In stock
50 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo.
KW-2478 demonstrates antiproliferative activities against human MM cells, OPM-2/GFP, KMS-11, RPMI 8226, and NCI-H929 with IC50 of 0.30, 0.34, 0.39, and 0.12 uM respectively, associated with degradation of well-known client proteins as well as FGFR3, c-Maf, and cyclin D1.
KW-2478 suppresses tumor growth in NCI-H929 models.

物理化学性质&存储条件

分子量	611.129
分子式	C30H43ClN2O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-{2-ethyl-3,5dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl}-N,N-bis(2-methoxyethyl)acetamide monohydrochloride

参考文献

1. Nakashima T, et al. Clin Cancer Res. 2010 May 15;16(10):2792-802.

2. Ishii T, et al. Blood Cancer J. 2012 Apr;2(4):e68.

3. Yong K, et al. Br J Cancer. 2016 Jan 12;114(1):7-13.

4. Agatsuma T, et al. Bioorg Med Chem. 2002 Nov;10(11):3445-54.

KW-2478 (KW2478;KW 2478)

生物&药学活性

物理化学性质&存储条件

参考文献

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KW-2478 (KW2478;KW 2478)

生物&药学活性

物理化学性质&存储条件

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