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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-KUNG94
KUNG94

Chemical Structure : KUNG94

CAS No.: 2134571-29-0

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KUNG94 (KUNG-94, KUNG 94)

货号: PC-60156Not For Human Use, Lab Use Only.

KUNG94 is a potent, selective Grp94 inhibitor with IC50 of 8 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KUNG94 is a potent, selective Grp94 inhibitor with IC50 of 8 nM.
    KUNG94 displays 10-fold selecticity over Hsp90α.
    KUNG94 shows antiproliferative activity against RPMI8226 cells with Gi50 of 1.4 uM, reduces LRP6 levels and induces apoptosis.

    物理化学性质&存储条件

    分子量 363.388
    分子式 C22H18FNO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5-(4-fluorobenzyl)-2,4-dihydroxyphenyl)(isoindolin-2-yl)methanone

    参考文献

    1. Khandelwal A, et al. ACS Med Chem Lett. 2017 Sep 1;8(10):1013-1018.

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