KUNG65 | Grp94 inhibitor | Probechem Biochemicals

Chemical Structure : KUNG65

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KUNG65 (KUNG 65)

货号: PC-49775Not For Human Use, Lab Use Only.

KUNG65 is a potent, selective glucose regulated protein 94 (Grp94) inhibitor with Kd value of 540 nM in fluorescence polarization assays, 73-fold selectivity over Hsp90α.

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生物&药学活性

KUNG65 is a potent, selective glucose regulated protein 94 (Grp94) inhibitor with Kd value of 540 nM in fluorescence polarization assays, 73-fold selectivity over Hsp90α.
Treatment with KUNG65 produced 38-40% migration (60% inhibition) at 500 nM after 24 h and exhibited good effects at lower concentrations in metastatic breast (MDA-MB-231) and prostate (PC3-MM2) cell lines.
KUNG65 also reduced the migratory capabilities aginst metastatic melanoma (SK-MEL-28) cells.
KUNG65 (2.5 uM) selectively targets Grp94 and induces the degradation of Grp94-specific client proteins without decreasing the levels of proteins that depend upon the cytosolic Hsp90 isoforms in in the metastatic cancer cell lines (MDA-MB-231, PC3-MM2, SK-MEL-28).

物理化学性质&存储条件

分子量	414.86
分子式	C23H20ClFO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-chloro-2-(2-(4-fluorobenzyl)phenethyl)-4,6-dihydroxybenzoate

参考文献

1. Crowley VM, et al. Chemistry. 2017 Nov 7;23(62):15775-15782.

KUNG65 (KUNG 65)

生物&药学活性

物理化学性质&存储条件

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KUNG65 (KUNG 65)

生物&药学活性

物理化学性质&存储条件

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