KU675 |CAS:1535221-75-0 Probechem Biochemicals

Chemical Structure : KU675

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KU675 (KU-675;KU 675)

货号: PC-60609Not For Human Use, Lab Use Only.

KU675 is a second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively.

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生物&药学活性

KU675 is a second-generation C-terminal Hsp90 inhibitor with Kd of 191 and 726 uM for Hsp90α and Hsp90β, respectively.
KU675 ialso displays binding to Hsc70 with Kd of 76.3 uM, reduces the expression of Hsc70-specific client proteins.
KU675 i demonstrates antiproliferative effect against PC3MM2 cells with IC50 of 5-10 uM, for LNCap-LN3, LAPC-4, and C4-2 cells, IC50 if 1.5-2.5 uM.
KU675 i exhibits greater inhibition of Hsp90’s protein folding function than the N-terminal inhibitor, 17-AAG.

物理化学性质&存储条件

分子量	455.939
分子式	C24H26ClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-chlorophenyl)-3-(8-methyl-2-oxo-7-(2-(piperidin-2-yl)ethoxy)-2H-chromen-3-yl)urea

参考文献

1. Liu W, et al. Mol Pharmacol. 2015 Jul;88(1):121-30.

2. Burlison JA, et al. J Org Chem. 2008 Mar 21;73(6):2130-7.

KU675 (KU-675;KU 675)

生物&药学活性

物理化学性质&存储条件

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KU675 (KU-675;KU 675)

生物&药学活性

物理化学性质&存储条件

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